Publication detail
MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS
JADRNÁ, L. ZUMBERG, I. LISICKÝ, O. JAGOŠ, J. ČMIEL, V. BURŠA, J.
English title
MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS
Type
Paper in proceedings outside WoS and Scopus
Language
en
Original abstract
Arterial endothelium lies right at the interface between blood flow and the aortic wall and its disruption has been hypothesized as one of the crucial players in atherosclerosis development and progression. To address the physiological conditions of arterial endothelium we conducted a study of endothelial cell behaviour under shear stress. By interconnecting tailored experiments of cells under shear flow with computational modelling, we gained further insights into the behaviour of individual cells under shear stress. The main aim of the study was to evaluate the viability and extend the capabilities of previously-developed FEM structural models of cells [1,2]. We hypothesize that excessive deformation may lead up to a disruption of the cell attachment to the underlying substrate and thus play a major role in lipid penetration through the endothelium.
Keywords in English
Endothelial cells; atherosclerosis; shear flow
Released
2023-07-09
Publisher
ESB
Location
Maastricht
Book
ESB 2023 BOOK OF ABSTRACTS
Pages count
1
BIBTEX
@inproceedings{BUT184913,
author="Lucie {Jadrná} and Inna {Zumberg} and Ondřej {Lisický} and Jiří {Jagoš} and Vratislav {Čmiel} and Jiří {Burša}",
title="MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS",
booktitle="ESB 2023 BOOK OF ABSTRACTS",
year="2023",
number="28",
pages="1",
publisher="ESB",
address="Maastricht",
url="https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf"
}