Publication detail

FE models of stress-strain states in vascular smooth muscle cell

BURŠA, J. LEBIŠ, R. JANÍČEK, P.

English title

FE models of stress-strain states in vascular smooth muscle cell

Type

Peer-reviewed article not indexed in WoS or Scopus

Language

en

Original abstract

The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of computational modelling of SMCs under physiological load are discussed.

Keywords in English

smooth muscle cell, finite element method, tensegrity, mechanical test, computational simulation

Released

2006-10-10

Publisher

IOS Press

Location

Nieuwe Hemweg 6B, 1013 BG, The Netherlands

ISSN

0928-7329

Journal

TECHNOLOGY AND HEALTH CARE

Volume

14

Number

4,5

Pages from–to

311–320

Pages count

10

BIBTEX


@article{BUT43914,
  author="Jiří {Burša} and Radek {Lebiš} and Přemysl {Janíček}",
  title="FE models of stress-strain states in vascular smooth muscle cell",
  journal="TECHNOLOGY AND HEALTH CARE",
  year="2006",
  volume="14",
  number="4,5",
  pages="311--320",
  issn="0928-7329"
}