Publication detail

The impact of Intra-luminal Thrombus failure on the mechanical stress in the wall of Abdominal Aortic Aneurysms

POLZER, S. BURŠA, J. SWEDENBORG, J. GASSER, T.

English title

The impact of Intra-luminal Thrombus failure on the mechanical stress in the wall of Abdominal Aortic Aneurysms

Type

Peer-reviewed article not indexed in WoS or Scopus

Language

en

Original abstract

The role of the Intra-luminal Thrombus (ILT) in Abdominal Aortic Aneurysm (AAA) rupture is controversial and it is still not clear if an ILT increases or decreases AAA rupture risk. Specifically, signs of bleeding in the ILT are thought to increase AAA rupture risk. In order to further investigate this hypothesis, intact AAAs (n=4) with clear signs of ILT rupture in Computer Tomography Angiography (CT-A) images were investigated. To this end two cases were investigated: an ILT failure extracted directly from the CT-A data and a hypothetical ILT fissure connecting the lumen with the underlying aneurysm wall. Wall stress distributions were predicted based on the detailed Finite Element (FE) models. The study showed that the ILT rupture, as extracted from the CT-A data, can increase the mechanical stress in the underlying wall by up to 30%. The largest impact on the wall stress was observed if the ILT failure reaches the aneurysm wall or if it involves large parts of the ILT. In contrast, a concentric failure in the medial ILT not reaching the wall has almost no impact on the wall stress distribution. Finally, the insertion of the hypothetical crack in the ILT can even double the stress of the underlying wall. In conclusion, the ILT failure redistributes the wall stress and, if it reaches the wall or involves large parts of the ILT, it can potentially trigger the AAA rupture.

Keywords in English

Intra-luminal Thrombus, failure risk, finite element analysis, Abdominal Aortic Aneurysms

Released

2011-02-18

Publisher

Elsevier

ISSN

1078-5884

Journal

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Volume

41

Number

4

Pages from–to

467–473

Pages count

7

BIBTEX


@article{BUT72588,
  author="Stanislav {Polzer} and Thomas Christian {Gasser} and Jesper {Swedenborg} and Jiří {Burša}",
  title="The impact of Intra-luminal Thrombus failure on the mechanical stress in the wall of Abdominal Aortic Aneurysms",
  journal="EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY",
  year="2011",
  volume="41",
  number="4",
  pages="467--473",
  issn="1078-5884"
}