Publication detail

Tensegrity finite element models of mechanical tests of individual cells

BURŠA, J. HOLATA, J. LEBIŠ, R.

English title

Tensegrity finite element models of mechanical tests of individual cells

Type

Peer-reviewed article not indexed in WoS or Scopus

Language

en

Original abstract

A three-dimensional finite element model of a vascular smooth muscle cell is based on models published recently; it comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing the cytoskeleton. In contrast to previous models of eucaryotic cells, this tensegrity structure consists of several parts. Its external and internal parts number 30 struts, 60 cables each, and their nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate load transmission from the extracellular space to the nucleus or centrosome via membrane receptors (focal adhesions); the ability of the model was tested by simulation of some mechanical tests with isolated vascular smooth muscle cells. Although material properties of components defined on the basis of the mechanical tests are ambiguous, modelling of different types of tests has shown the ability of the model to simulate substantial global features of cell behaviour, e.g. action at a distance effect or the global load-deformation response of the cell under various types of loading. Based on computational simulations, the authors offer a hypothesis explaining the scatter of experimental results of indentation tests.

Keywords in English

Cell biomechanics; Tensegrity structure; Cytoskeleton; Computational model

Released

2012-04-16

Publisher

Elsevier Science B.V.

Location

Amsterdam

ISSN

0928-7329

Journal

TECHNOLOGY AND HEALTH CARE

Volume

20

Number

2

Pages from–to

135–150

Pages count

16

BIBTEX


@article{BUT88700,
  author="Jiří {Burša} and Jakub {Holata} and Radek {Lebiš}",
  title="Tensegrity finite element models of mechanical tests of individual cells",
  journal="TECHNOLOGY AND HEALTH CARE",
  year="2012",
  volume="20",
  number="2",
  pages="135--150",
  issn="0928-7329"
}