Detail publikace

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC LUNG MODEL

LÍZAL, F. ELCNER, J. JEDELSKÝ, J. JÍCHA, M.

Anglický název

EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC LUNG MODEL

Typ

Článek recenzovaný mimo WoS a Scopus

Jazyk

en

Originální abstrakt

The inhalation route for administration of medicaments is becoming more and more popular in recent years. The reason is non-invasiveness of the method and instantaneous absorption of drugs to the blood circulation. It is necessary to deliver exact amount of drug to the specific segment because of occurrence of diverse diseases in different segments of lungs. The aim of our work is to contribute to better understanding of transport and deposition of aerosolized drugs in lungs and hence to more effective treatment of respiratory diseases due to the targeted drug delivery. We provided measurements of aerosol deposition in segmented realistic model of lungs without a mouth cavity. Monodisperse particles marked with fluorescein were supplied to the model. The model was then disassembled to segments and each segment was rinsed with isopropanol, whereby fluorescent samples were created. Each sample was analysed by fluorometer and an amount of aerosol deposited in the segment was calculated. Experiences obtained by this study were used for creation of a new model with the mouth cavity. This model will be used for future studies with porous and fiber aerosols.

Klíčová slova anglicky

realistic lung model, lung model, lung deposition, aerosol deposition, aerosol

Vydáno

2011-03-01

Nakladatel

VŠB – Technická univerzita Ostrava

Místo

Ostrava

ISSN

1210-0471

Časopis

Transaction of the VŠB-Technical university of Ostrava, Mechanical series

Ročník

LVI

Číslo

3/2010

Strany od–do

109–114

Počet stran

6

BIBTEX


@article{BUT50937,
  author="František {Lízal} and Jakub {Elcner} and Jan {Jedelský} and Miroslav {Jícha}",
  title="EXPERIMENTAL STUDY OF AEROSOL DEPOSITION IN A REALISTIC LUNG MODEL",
  journal="Transaction of the VŠB-Technical university of Ostrava, Mechanical series",
  year="2011",
  volume="LVI",
  number="3/2010",
  pages="109--114",
  issn="1210-0471"
}